I've run into two quest-ending bugs. I couldn't find answers to them, so figured I'd float them here, just in case.
1. The Big Dig: Bobbi No-Nose opens a window in a warehouse door in Goodneighbor and tells me she has a job for me, and invites me in to discuss it. The door is locked and requires a key. Apparently, no NPC holds that key. Banging on the door, shooting the door, leaving and coming back...none of that changes anything. One website told me to use the ~ key to open the developers' console and use the UNLOCK command on the door...but that didn't work, either. After I type "unlock" the console says "door unlocked," but after closing the console nothing has changed. Maybe I'm doing it wrong.
2. A New Threat: I do several steps that lead up to building a robot workbench. The step after that is "Talk to Ada," a robot that is available to be a companion (although I didn't take him). When I try to talk to Ada, he says "If you're here you must have built the workbench." The expected dialog tree never appears. I've tried stocking the workbench with parts, going away/coming back, etc., but Ada never goes past that greeting. I could not find this bug addressed online. Maybe I'll kill Ada.
Neither of these are major quests. I can just ignore them, and probably will have to. But having started them, I'd like to proceed.