1. CTRL-left click transfers all of an item from one inventory to another (so instead of searching around for all of the [whatever] or using the sort button, then shift-clicking the stacks one by one, you just find one stack and CTRL-click it and it transfers them all.)
2. This site
for planning factory layouts. It isn't an efficiency calculator like the last one, just a layout planner so you can figure out how big to make your foundations, how to run everything so that you don't end up with conveyor/power spaghetti.
3. Holding CTRL while placing an item forces it to lock to the global grid (to make sure that everything is square.) That much I knew. What I didn't know is that if you hold CTRL while placing an item over another item, it replaces the existing item. For example, say you built an entire building out of walls. Now you want every other panel on the second row to be a window. Instead of removing every other panel and then placing windows in the gaps, just select the windows, hold CTRL, and it will automatically replace the wall with the window.
Related to #2.
Today I'm making an attempt at my second factory rebuild. Last time all I had was constructors and smelters. This time I'm taking more advanced materials into account (assemblers, blenders, manufacturers, refineries, foundries, etc.) I've already decided to separate things into separate sub-factories: A universal storage building (possibly combined with or next to a transport hub), a foundry, a refinery (built next to the water for convenience), a first-level production building (single-material recipes - screws, plates, etc), an advanced production factory (assemblers, manufacturers, etc.) In order to make the space more practical, I'm thinking about spreading them out. I've already decided to (eventually) make a specialized ammo/explosives plant just to get that overhead away from my main base, and I may move the first-level production somewhere else and ship the single-ingredient products in.
But it is challenging to plan for this. According to a comment I found, they're broken down like this:
Standard recipes are currently repartited into : 3 smelter ; 2 foundry ; 30 constructor ; 27 assembler ; 18 manufacturer ; 13 raffinery ; 7 Blender ; 2 accelerator ; 10 packager (water & sulfuric acid are requested for outputing waste to the Sink)
And given that I haven't unlocked the blender or manufacturer yet, that's a lot to plan around. What I want to avoid is having to madly rearrange conveyors every time I need a different item, while avoiding laying out 50+ Assemblers. What I need to do is figure out which production items are used in vast quantities (like steel beams and reinforced plates), and which are just used in a few offhand recipes here and there. Maybe it would make sense to set aside a smaller factory just for space elevator production, as those tend not to be used for much besides the elevator and a few research items. I could just put a storage buffer on each in case I needed a few later.